Nutrition
-
Randomized Controlled Trial Clinical Trial
Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids.
The potential pathogenicity of free radicals may have a pivotal role in ulcerative colitis. Fish oil omega-3 fatty acids exert anti-inflammatory effects on patients with ulcerative colitis (UC), but the precise mechanism of the action of fish oil on oxidative stress is still controversial. The aim of the present work was to verify the blood oxidative stress in patients with UC and determine whether the association of sulfasalazine to fish oil omega-3 fatty acids is more effective than isolated use of sulfasalazine to reduce the oxidative stress. ⋯ The results indicated that plasma oxidative stress occurs in patients with UC, and there was a significant decrease when the patients used sulfasalazine plus fish oil omega-3 fatty acids. However, there was no improvement in most laboratory indicators, sigmoidoscopy, and histology scores. The results suggested that omega-3 fatty acids may act as free radical scavengers protecting the patients against the overall effect of oxidative stress.
-
Randomized Controlled Trial Clinical Trial
Soluble tumor necrosis factor-alpha receptor type 1 during selenium supplementation in psoriasis patients.
Tumor necrosis factor-alpha (TNF-alpha) and its receptors play important roles in the induction and maintenance of psoriatic lesions. Selenium (Se), a trace element with immunomodulatory properties, is usually decreased in psoriasis patients. We examined the influence of Se supplementation on soluble TNF-alpha receptor type 1 (sTNF-R1) and topical treatment in psoriasis patients. ⋯ Increased level of sTNF-R1 may be an indicator of active psoriasis. Supplementation with selenomethionine was ineffective as adjuvant treatment in plaque psoriasis and may contribute to the maintenance of elevated TNF-R1 concentration in psoriasis patients despite the remission of skin lesions.
-
Randomized Controlled Trial Clinical Trial
Effect of hypocaloric meals with different macronutrient compositions on energy metabolism and lung function in obese women.
We investigated the effect of hypocaloric mixed diets with different proportions of carbohydrate, protein, and fat on resting metabolic rate and the thermic effect of food in obese women. ⋯ Obese women with normal lung function tests and consuming mixed hypocaloric diets showed no alteration in resting metabolic rate and a reduced or absent thermic effect of food independently of the macronutrient composition.
-
Randomized Controlled Trial Clinical Trial
Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children.
Dietary components such as vegetable or probiotic microorganisms have been proposed as an alternative solution to decrease Helicobacter pylori colonization in at-risk populations. Some strains of lactic acid bacteria have been shown to exert bacteriostatic or bactericidal effects against H. pylori in in vitro and in vivo models of infection by this pathogen. We investigated whether regular ingestion of a dietary product containing Lactobacillus johnsonii La1 or L. paracasei ST11 would interfere with H. pylori colonization in children. ⋯ Regular ingestion of a product containing Lactobacillus La1 may represent an interesting alternative to modulate H. pylori colonization in children infected by this pathogen.
-
Randomized Controlled Trial Clinical Trial
Some magnesium status indicators and oxidative metabolism responses to low-dietary magnesium are affected by dietary copper in postmenopausal women.
A study with human volunteers was conducted to ascertain whether a low intake of copper (Cu) would exacerbate the response to a deficient intake of magnesium (Mg). ⋯ The findings indicated that, in short-term magnesium depletion experiments, the response to depletion can be influenced by other dietary factors including copper intake and a high magnesium intake before depletion, and that 100 mg of Mg/d is inadequate for postmenopausal women.