International journal of clinical practice
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisThe Effect of Grape Seed Extract Supplementation on Oxidative Stress and Inflammation ─ A Systematic Review and Meta-Analysis of Controlled Trials.
Grape seed extract (GSE) seems to have antioxidant and anti-inflammatory properties due to its high polyphenolic content. Nevertheless, the scientific literature in this field is controversial and inconclusive. Therefore, we aimed to conduct a systematic review and meta-analysis of controlled trials to evaluate the effect of supplementation with GSE on biomarkers of oxidative stress and inflammation. ⋯ It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisInfarct volume and outcome of cerebral ischemia, a systematic review, and meta-analysis.
Multiple studies have evaluated the accuracy of infarct volume (IV) as a predictor of outcome in patients with ischaemic stroke; however, no study has systematically reviewed the results of these studies. ⋯ The results of the meta-analysis revealed a significant association between IV and unfavourable functional outcomes in patients with ischaemic stroke.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisPrognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 patients: A systematic review and meta-analysis.
Neutrophil-to-lymphocyte ratio (NLR) is an accessible and widely used biomarker. NLR may be used as an early marker of poor prognosis in patients with COVID-19. ⋯ Higher values of NLR were associated with severity and all-cause mortality in hospitalised COVID-19 patients.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisAssociation between elevated brain natriuretic peptide levels and weaning failure: a systematic review and meta-analysis.
Cardiovascular dysfunction has been reported as an important mechanism of weaning failure, and recent data suggest that elevated brain natriuretic peptide (BNP) levels is associated with an increased risk of weaning failure. Therefore, we performed this meta-analysis to evaluate the correlation between elevated BNP levels and weaning failure in critically ill patients subject to mechanical ventilation. ⋯ This meta-analysis showed that increased plasma BNP concentration was associated with weaning failure in ICU patients.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisEffect of Probiotics Supplementation on Disease Progression, Depression, General Health and Anthropometric Measurements in Relapsing-Remitting Multiple Sclerosis Patients: A Systematic Review and Meta-analysis of Clinical Trials.
Probiotics may have a promising role in chronic autoinflammatory diseases. The current systematic review and meta-analysis investigated the effects of probiotics on disease progression, depression, general health, and anthropometric measurements in Relapsing-Remitting Multiple Sclerosis (RRMS) patients. ⋯ Our findings revealed that probiotics supplementation can improve disease progression, suppress depression, and general health in MS patients; although, further investigations may be needed.