International journal of clinical practice
-
Int. J. Clin. Pract. · Nov 2021
Meta AnalysisEffect of Artemisia extract on glycemic control: A systematic review and meta-analysis of randomized controlled trial.
Animal and human studies have indicated anti-diabetic effect of Asteraceae. The present study aimed to systematically review and analyse randomized controlled trials assessing the effect of Artemisia extract on glycemic status in patients with impaired glycemic control. ⋯ Supplementation with Artemisia extract may reduce HOMA-IR, but beneficial effects on other markers such as FBG requires further investigations.
-
Int. J. Clin. Pract. · Nov 2021
Meta AnalysisThe association between apolipoprotein A-1 plasma level and premature coronary artery disease; a systematic review and meta-analysis.
Apolipoprotein A-1 (Apo A-1) is a constituent of high-density lipoprotein (HDL) and emerging evidences put forward a potential association between Apo A-1 plasma levels and premature coronary artery disease (pCAD). The aim of the present study is to gather relative literature and perform a systematic review and meta-analysis regarding the association between serum ApoA-1 levels and pCAD. ⋯ In conclusion, there seems to be a significant association between the serum levels of ApoA-1 and pCAD. However, all of the included studies had a case-control design and since there is no good quality and prospective cohort studies included, reliability of the current evidence is debatable. Therefore, further well-designed cohort studies are required to assess the impact of serum ApoA-1 reduction on pCAD onset.
-
Int. J. Clin. Pract. · Nov 2021
Meta AnalysisComparison of efficacy and safety of gabapentin and duloxetine in painful diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials.
In patients with diabetes mellitus, painful diabetic peripheral neuropathy (PDPN) is a frequent complication and can cause poor quality of life. We compared the efficacy and safety of duloxetine with those of gabapentin in patients with PDPN through a systematic review and meta-analysis of randomised controlled trials. ⋯ No significant differences were observed in the efficacy of duloxetine and gabapentin when treating patients with PDPN.
-
Int. J. Clin. Pract. · Nov 2021
Meta AnalysisEffect of Orlistat on serum Uric acid level in adults: A systematic review and meta-analysis of randomized controlled trials.
Hyperuricemia increases the risk of gout and cardiovascular diseases. Obesity increases the risk of hyperuricemia while weight loss (>5 kg) has been reported to decrease urate. The effects of orlistat on serum uric acid (SUA) are still controversial. The aim of this meta-analysis was to evaluate the influence of orlistat on SUA levels in adults. ⋯ We found a significant reduction in SUA following orlistat therapy in adults.
-
Int. J. Clin. Pract. · Nov 2021
Meta AnalysisAccuracy of pecarn decision rule in minor blunt head trauma in pediatric emergency department: A meta-analysis.
Paediatric Emergency Care Applied Research Network (PECARN) is a useful Clinical Decision Support Tool (CDST) to identify traumatic brain injuries and reduce the use of head computed tomography (CT) scans among paediatric patients. The present Meta-analysis aims to evaluate the diagnostic accuracy of the PECARN rule from 2009 to 2020 in children with a very low risk of blunt head trauma. ⋯ The present analysis indicates the PECARN decision tool as an accurate CDST in low-risk minor BHT cases in children below two years of age and can become a valuable tool in reducing Head CT scan overuse in paediatric emergency departments.