International journal of clinical practice
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialRifaximin microbial resistance and its efficacy and safety as a secondary prophylaxis of hepatic encephalopathy in patients with HCV related cirrhosis.
Rifaximin is an oral antibiotic with promising efficacy in the reduction of hepatic encephalopathy (HE) recurrence. Development of microbial resistance to rifaximin is not studied yet in HE. The study aim was to assess the microbial resistance, safety and efficacy of rifaximin as secondary prophylaxis of HE. ⋯ Rifaximin succeeded to maintain remission from new episodes of HE in hepatitis C virus cirrhotic patients with limited potential for development of microbial resistance over the study period. ClinicalTrials.gov Identifier: NCT04736836.
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialEvaluation of Ultrasound-Guided Adductor Canal Block With Two Different Concentration of Bupivacaine in Arthroscopic Knee Surgery, A Feasibility Study.
The application of regional anaesthesia techniques as a component of multimodal analgesia in knee arthroscopic surgeries increases the quality of postoperative analgesia. Adductor canal block (ACB) is an effective "motor sparing" analgesia technique used in knee surgeries. This study aimed to evaluate the efficacy of ACB using two different concentrations of local anaesthetic in terms of analgesic requirements and pain density in patients undergoing knee arthroscopy. ⋯ In arthroscopic knee surgery, ACB interventions with 0.25% and 0.16% concentrations of bupivacaine were similar in terms of postoperative analgesic efficacy, and they increased the quality of multimodal analgesics when compared with the control group.
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialThe Participation of Arab Women in Randomized Clinical Trials for Cardiovascular Diseases.
Women's enrolment in randomised clinical trials (RCTs) raises the attention of medical personnel and evidence-based medicine researchers to achieve the highest possible quality and transparency of conducted studies. This study aims to demonstrate various patterns and relationships of women's enrolment in cardiovascular RCTs conducted in Arab countries. ⋯ As a result of the huge importance of RCTs in the medical field, and to reduce biases arising from inaccurate representation of different study populations, women's enrolment in Arab cardiovascular trials should be pre-planned and based on the percentage of women among the studied disease population.
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialDoes Naringenin Supplementation Improve Lipid Profile, Severity of Hepatic Steatosis, and Probability of Liver Fibrosis in Overweight/Obese Patients with NAFLD? A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.
Naringenin has been reported to have some promising pharmacological effects on the management of obesity and related metabolic complications including non-alcoholic fatty liver disease (NAFLD). Therefore, the present clinical trial study was done to assess the effects of naringenin supplementation on lipid profile, aminotransferase levels, severity of steatosis, as well as probability of fibrosis in overweight/obese patients with NAFLD. ⋯ Our findings revealed that daily intake of 200 mg of naringenin for 4 weeks had beneficial effects on lipid profile and percentages of NAFLD grades as an indicator for the severity of hepatic steatosis. Although, NFS values and serum levels of aminotransferase enzymes including AST and ALT did not remarkably change.
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialAssessment of severity and mortality of COVID-19 with anti-A1 and B IgM isohemagglutinins, a reflection of the innate immune status.
The relationship between the innate immune system that creates the polysaccharide antibody response and COVID-19 is not fully understood. In this study, it was aimed to determine the predictive values of isohaemagglutinins in COVID-19 severity/mortality. ⋯ Anti-B and anti-A1 isohaemagglutinins, which are an expression of the innate immune system, can be used to predict the severity and mortality of COVID-19 disease.