International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
ReviewSevere and life-threatening COVID-19-related mucocutaneous eruptions: A systematic review.
Earlier diagnosis and the best management of virus-related, drug-related or mixed severe potentially life-threatening mucocutaneous reactions of COVID-19 patients are of great concern. These patients, especially hospitalised cases, are usually in a complicated situation (because of multi-organ failures), which makes their management more challenging. In such consultant cases, achieving by the definite beneficial management strategies that therapeutically address all concurrent comorbidities are really hard to reach or even frequently impossible. ⋯ We can conclude vascular injuries may be the most common cause of severe dermatologic manifestations of COVID-19, which is concordant with many proposed hypercoagulation tendencies and systemic inflammatory response syndrome as one of the most important pathomechanisms of COVID-19 so the skin may show these features in various presentations and degrees.
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The impact of annual flu vaccination on the patients' clinical course with COVID-19 and the outcome were tested. ⋯ Although the benefits of the influenza vaccine for preventing disease and reducing morbidity in influenza patients are well established, no differences in outcomes for hospitalised patients with COVID-19 who received their annual influenza vaccination versus the non-vaccinated cohort were evident. There is a need for future meta-analyses, including randomised controlled studies in which the number of cases is increased to validate these findings.
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Int. J. Clin. Pract. · Dec 2021
Observational StudyThe safety profile of biologic agents in comparison with non-biologic systemic agents, and topical compounds in the management of psoriasis - a 30-month prospective, observational cohort study.
Although biologic agents (BAs) are very effective, solid data proving they are safer than other therapies in psoriasis are still lacking. ⋯ While BAs were the most effective therapies, they were associated with higher rates of treatment discontinuation and adverse events in comparison with other forms of therapy.
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Int. J. Clin. Pract. · Dec 2021
How to identify the most suitable questionnaires and rating scales for your research and clinical practice?
Selection of the most suitable instrument for a health outcome or exposure assessment is challenging, as there are many different instruments and their versions, most with unknown validity. ⋯ These guidelines facilitate the objective choice of the most suitable instrument in clinical practice by making the search simple, systematic and time-effective.
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Int. J. Clin. Pract. · Dec 2021
Serial measurement of soluble endoglin for risk assessment at the diagnosis of fetal growth restriction.
In this study, we aimed to investigate the soluble endoglin (sEng) levels in pregnant women with fetal growth restriction (FGR) and to examine the possible relation of the sEng levels with the time remaining to delivery and maternal and fetal complications. ⋯ We did not find a statistically significant relationship between the sEng level and the time remaining to the time of delivery in pregnant women with FGR. We found no statistically significant difference in sEng level between the groups in pregnant women with fetuses with FGR with or without maternal and fetal complications.