International journal of clinical practice
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To evaluate the bowel habits of patients with acne vulgaris. ⋯ Further large sample sized studies are needed on this subject, as there is strong evidence about brain-gut-skin axis existence.
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Int. J. Clin. Pract. · Dec 2021
Complimentary effects on glycemic and non-glycemic parameters between responder and non-responders treated with pioglitazone and canagliflozin in drug naïve subjects with type 2 diabetes.
The aim of this study was to investigate the differential regulation of metabolic parameters between pioglitazone and canagliflozin in relation to their glycaemic efficacies. ⋯ (i) Glycaemic efficacy of pioglitazone is linked to body weight and atherogenic lipids while this is not the case with canagliflozin. (ii) Responders (or non-responders) to pioglitazone have some distinct features from non-responders (or responders) to canagliflozin. Collectively, a combination of pioglitazone and canagliflozin may compensate for each other's metabolic drawbacks or augment their advantages, thereby achieving overall improvements in the metabolic profiles and pathogenic defects of patients with T2DM.
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Int. J. Clin. Pract. · Dec 2021
Reconstruction of Achilles region defects: a single-center experience.
Reconstruction of Achilles tendon and the overlying tissue defects is a challenging undertaking. The spectrum of available repair methods range from secondary healing to the use of free flaps. The aim of this study was to discuss reconstruction options and to help the surgeon to select reliable approach to achieve favourable outcomes. ⋯ Orthoplastic reconstruction should be kept in mind for Achilles tendon defects. The use of special digital imaging techniques facilitates flap surgery and helps minimise the risk of flap complications. Conventional approaches are suitable for shallow small skin lesions. Local flaps are good options for deeper skin defects owing to superior aesthetic outcomes. Super-thin free flaps offer a distinct advantage in skillful hands. The use of multi-content free chimeric flaps for reconstruction of complex defects facilitates better anatomical repair. Cross leg or flow-through flaps may be considered in patients with compromised distal circulation. Selection of the most reliable approach for Achilles reconstruction is a key imperative to achieve favourable outcomes.
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Int. J. Clin. Pract. · Dec 2021
Expression of Leptin mRNA as Non-Invasive Biomarker in Type 2 Diabetes Mellitus.
Leptin, an adipocyte-derived signalling molecule that plays important role in the regulation of energy balance, body weight and glucose metabolism. ⋯ This study shows that the reduced leptin mRNA expression level is significantly associated with T2DM and could be used as a predictive and diagnostic biomarker for T2DM.