International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
Meta AnalysisExploration of severe Covid-19 associated risk factor in China: meta-analysis of current evidence.
This meta-analysis aimed to explore potential risk factors for severe Covid-19. ⋯ There are significant differences in clinical characteristics between the severe and non-severe Covid-19 patients. Many factors are related to the severity of the disease, which can help clinicians to differentiate severe patients from non-severe patients.
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Int. J. Clin. Pract. · Dec 2021
Multicenter StudySafety and efficacy of alirocumab in real life setting: analysis of the Belgian cohort of the ODYSSEY APPRISE trial with review of current lipid treatment guidelines and its implementation in clinical practice.
As lipid targets became more stringent in the latest ESC/EAS guidelines, many patients on statin monotherapy are left above their risk-based target, increasing the need for lipid-lowering therapies. The results of the ODYSSEY APPRISE study were recently published by Gaudet et al In this trial, alirocumab (a PCSK9 inhibitor) was investigated in high cardiovascular risk patients in a real-life setting. ⋯ In a real-life setting, alirocumab is both well-tolerated, safe and very effective in reducing LDL-c in this Belgian cohort. In clinical practice, more patients should be initiated on the add-on, non-statin lipid-lowering therapy in order to reach their risk-based lipid target.
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Int. J. Clin. Pract. · Dec 2021
ReviewDepresssion, Anxiety and Other Cognitive Consequences of Social Isolation: drug and non-drug treatments.
During the COVID-19 pandemic, quarantine and staying at home is advised. The social relationship between people has become deficient, and human social isolation (SI) has become the consequence of this situation. It was shown that SI has made changes in hippocampal neuroplasticity, which will lead to poor cognitive function and behavioural abnormalities. There is a connection between SI, learning, and memory impairments. In addition, anxiety-like behaviour and increased aggressive mood in long-term isolation have been revealed during the COVID-19 outbreak. ⋯ This manuscript aims to review improved cognitive impairments induced by SI during COVID-19.
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Int. J. Clin. Pract. · Dec 2021
Meta AnalysisThe effects of capsinoids and fermented red pepper paste supplementation on Glycemic Control: A systematic review and meta-analysis of randomized controlled trials.
The present systematic review and meta-analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control. ⋯ Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA-IR but significantly reduce glucose in people older than 40 years.
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Int. J. Clin. Pract. · Dec 2021
ReviewCurrent laboratory tests for diagnosis of hepatitis B virus infection.
Hepatitis B virus (HBV) has a long history in human infectious diseases. HBV infection can progress chronically, leading to cancer. After introduction of a vaccine, the overall incidence rate of HBV infection has decreased, although it remains a health problem in many countries. ⋯ An effective diagnostic approach and current updated knowledge of treatment response monitoring are important for HBV infection management. Brand new ultrasensitive and accurate immunologic methods may pave the way to manage HBV infection in parallel with immunotherapy era.