International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
Community Pharmacy Cognitive Services During the COVID-19 Pandemic: A Descriptive Study of Practices, Precautions Taken, Perceived Enablers and Barriers, and Burnout.
The objectives of this study were to identify community pharmacist (CP)-led cognitive services and CPs' precautions taken related to COVID-19, perceived enablers and barriers related to pharmaceutical services and burnout levels during the COVID-19 pandemic. ⋯ To increase the preparedness of pharmacists for future pandemics or disasters, this study highlighted CP-led cognitive services, precautions taken related to COVID-19, perceived enablers and barriers and burnout during the COVID-19 pandemic. Pharmaceutical services guidelines that could be followed during a pandemic or other disaster should be designed by addressing these findings.
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Int. J. Clin. Pract. · Dec 2021
The Impact of the First Wave of the COVID-19 Pandemic on Parents of Children with Externalising Difficulties in Ireland: A Longitudinal Cohort Study.
This longitudinal cohort study aimed to examine the impact of the first wave of the COVID-19 pandemic in Ireland on parents of children with externalising difficulties, in comparison to parents of children without such difficulties. ⋯ Results provide important information regarding the trajectory of psychological outcomes in parents of children with externalising difficulties over the first wave of the COVID-19 pandemic, highlighting the need for increased parental supports during, and after, the COVID-19 pandemic.
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Int. J. Clin. Pract. · Dec 2021
Role of hepatosteatosis in HBsAg seroconversion in HBeAg-negative chronic hepatitis B patients.
In chronic Hepatitis B virus (HBV) infection, certain individual and viral characteristics such as advanced age, presence of hepatic steatosis (HS), normal ALT levels, initially negative HBeAg and HBV DNA, and genotype of the virus are associated with HBsAg seroclearance and seroconversion. Herein, we report the results of our study evaluating the association between hepatosteatosis and HbsAg seroconversion. ⋯ The presence of mild HS in HBeAg negative chronic hepatitis B patients contributes to HBsAg seroconversion. Further studies are required to better understand the relationship between steatosis and HBsAg seroconversion.
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Int. J. Clin. Pract. · Dec 2021
Observational StudyExternal validation and Comparison of two versions of simplified sequential organ failure assessment scores to predict prognosis of septic patients.
Evidence shows that simplified SOFA scoring system has better clinical practice. ⋯ sa-SOFA appeared to have performed better than eSOFA score for predicting in-hospital mortality in patients' sepsis. Further large prospective studies are needed to externally validate.
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Int. J. Clin. Pract. · Dec 2021
Complimentary effects on glycemic and non-glycemic parameters between responder and non-responders treated with pioglitazone and canagliflozin in drug naïve subjects with type 2 diabetes.
The aim of this study was to investigate the differential regulation of metabolic parameters between pioglitazone and canagliflozin in relation to their glycaemic efficacies. ⋯ (i) Glycaemic efficacy of pioglitazone is linked to body weight and atherogenic lipids while this is not the case with canagliflozin. (ii) Responders (or non-responders) to pioglitazone have some distinct features from non-responders (or responders) to canagliflozin. Collectively, a combination of pioglitazone and canagliflozin may compensate for each other's metabolic drawbacks or augment their advantages, thereby achieving overall improvements in the metabolic profiles and pathogenic defects of patients with T2DM.