International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
Functional Deficit of Sense Organs as a risk factor for Cognitive Functional Disorder in Chinese Community Elderly People.
To explore the relationship between mild cognitive impairment (MCI) and sense organs functional deficit in community elderly people. ⋯ The sensory organs functional defects is associated with the mild cognitive impartment in Chinese elderly, especially in vision and hearing disorder.
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Int. J. Clin. Pract. · Dec 2021
Less postoperative pain and more frequent recurrence: Can this dilemma caused by the Stapled Hemorrhoidopexy Procedure be avoided?
Although early studies highlighted the advantages of stapled haemorrhoidopexy (SH) (minimal pain and a rapid return to work), long-term follow-up revealed that residual skin tags, external prolapsed haemorrhoids and recurrence were frequent. The aim of our study was to investigate whether the above-mentioned problems could be prevented by performing additional interventions (AIs) during SH. We compared SH with and without AIs in terms of pain, wound-healing time, patient satisfaction and recurrence. ⋯ Depending on the haemorrhoid characteristics, the use of more than one repair method provides the best results. Although AIs increase pain and wound-healing time, patient counselling enhances long-term satisfaction and success.
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Flavonoids and related compounds, such as quercetin-based antiviral drug Gene-Eden-VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The alkylated chalcones isolated from Angelica keiskei inhibit SARS-CoV proteases. In this study, we aimed to compare the anti-SARS CoV-2 activities of both newly synthesized chalcone derivatives and these two drugs. ⋯ Computational analyses identified eight compounds inhibiting each target, with binding affinity scores ranging from -4.370 to -2.748 kcal/mol along with their toxicological, ADME, and drug-like properties.
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Int. J. Clin. Pract. · Dec 2021
HDL subgroups and their paraoxonase-1 activity in the obese, overweight and normal weight subjects.
Obesity and overweight are significant public health problems because of higher risk for coronary artery disease (CAD). It is very important to determine new predictive markers to identify the CAD risk in obese and overweight. To aim this, we analysed HDL-C subgroups (HDL2-C and HDL3-C) and their paraoxonase-1 (PON-1) activity in obese, overweight and normal weight subjects. ⋯ Altered HDL-subgroups pattern and decreased PON-1 activities may cause increased risk for CVD in obese and overweight individuals. Therefore determination of HDL subgroups and their PON-1 activity may improve risk prediction compared with measuring total HDL-C levels and its PON-1 activity alone. Body weight and insulin resistance appear to have a role in the decreased HDL-C levels and PON-1activity in obese. Further studies should be conducted to shed more light on impacts of these markers in CVD.
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Int. J. Clin. Pract. · Dec 2021
Application of modified mini-clinical evaluation exercise in the cultivation of orthopedic students.
To apply the mini-clinical evaluation exercise (Mini-CEX) to orthopaedics and check its influence on clinical operational abilities and thinking abilities. ⋯ The modified Mini-CEX is suitable for orthopaedic education and could help cultivate interns' clinical thinking ability.