International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series.
Some levothyroxine unresponsive individuals with hypothyroidism are prescribed a natural desiccated thyroid (NDT) preparation such as Armour Thyroid® or ERFA Thyroid® . These contain a mixture of levothyroxine and liothyronine in a fixed ratio. We evaluated the response to NDT in individuals at a single endocrine centre in terms of how the change from levothyroxine to NDT impacted on their lives in relation to quality of life (QOL) and thyroid symptoms. ⋯ Significant symptomatic benefit and improvement in QOL was experienced by people with a history of levothyroxine unresponsive hypothyroidism treated with NDT, suggesting the need for further evaluation of NDT in this context.
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Int. J. Clin. Pract. · Dec 2021
Association of Celiac Disease with esophageal eosinophilia and eosinophilic esophagitis.
Aim of the study was to evaluate the association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia in children. ⋯ Although an association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia have been postulated in recent years, no exact relationship was established in this study. This is the first study reporting the performance of follow-up GI endoscopy with biopsies revealing the resolution of oesophageal eosinophilia.
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Int. J. Clin. Pract. · Dec 2021
Diagnostic Value of Platelet/lymphocyte Ratio (PLR) for Predicting Sentinel Axillary Lymph Node Positivity in Early Stage Breast Cancer Compared to Ultrasonography.
In breast cancer, the most important prognostic factor is axillary lymph node metastasis. However, there is no method which can diagnose axillary lymph node metastasis preoperatively with high sensitivity. The aim of this study was to evaluate the relationship between platelet/lymphocyte ratio (PLR) and sentinel lymph node metastasis in early-stage breast cancer. ⋯ The rate of success in diagnosing metastatic SLN in early-stage breast cancer is higher in PLR when compared with USG and other imaging methods.
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Int. J. Clin. Pract. · Dec 2021
The performance of artificial intelligence supported Thoracic CT to evaluate the radiologic improvement in patients with COVID-19 pneumonia: comparision pirfenidon vs. corticosteroid.
We aimed to investigate the effect of short-term pirfenidone treatment on prolonged COVID-19 pneumonia. ⋯ Antifibrotic agents can reduce fibrosis that may develop in the future. These can also help dose reduction and/or non-use strategy for methylprednisolone therapy, which has many side effects. Further large series and randomised controlled studies are needed on this subject.
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Int. J. Clin. Pract. · Dec 2021
The effect of the COVID-19 pandemic on dermatology consultation requests from adult and pediatric emergency departments.
This study aimed to determine the characteristics of dermatology consultation requests from the adult and paediatric emergency departments (EDs) of a university hospital during 8 months of the COVID-19 pandemic in 2020 and to compare them with the same 8 months of 2019. ⋯ COVID-19 restrictions and fear of COVID-19 infection might have discouraged patients from presenting to EDs because of skin problems; however, the easing of COVID-19 restrictions might lead to an increase in ED presentations, including non-urgent dermatological disorders. In order to reduce unnecessary use of EDs and prevent ED overcrowding, the general public should be educated about what constitutes a dermatological emergency.