Turk J Gastroenterol
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Turk J Gastroenterol · Jan 2013
PPAR-alpha agonist treatment increases trefoil factor family-3 expression and attenuates apoptosis in the liver tissue of bile duct-ligated rats.
Peroxisome proliferators-activated receptor alpha activation modulates cholesterol metabolism and suppresses bile acid synthesis. The trefoil factor family comprises mucin-associated proteins that increase the viscosity of mucins and help protect epithelial linings from insults. We evaluated the effect of short-term administration of fenofibrate, a peroxisome proliferators activated receptor alpha agonist, on trefoil factor family-3 expression, degree of apoptosis, generation of free radicals, and levels of proinflammatory cytokines in the liver tissue of bile duct-ligated rats. ⋯ The peroxisome proliferators-activated receptor alpha agonist fenofibrate significantly increased trefoil factor family-3 expression and decreased apoptosis and lipid peroxidation in the liver and attenuated serum levels of proinflammatory cytokines in bile duct-ligated rats. Further studies are needed to determine the protective role of fenofibrate in human cholestatic disorders.
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Turk J Gastroenterol · Jun 2012
Case ReportsFascioliasis: 3 cases with three different clinical presentations.
Fascioliasis, which is a zoonotic infestation caused by the trematode Fasciola hepatica (liver fluke), is primarily a disease of herbivorous animals such as sheep and cattle. Humans become accidental hosts through ingesting uncooked aquatic plants such as watercress. ⋯ As a result of newly introduced serological assays facilitating the diagnosis, there has been an increase in the number of reported cases. Here, we report the clinical and laboratory assessment and therapeutic approach of a series of three cases diagnosed (in order of) one week, three months and one and a half years after presentation of the first symptoms of the disease.
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Turk J Gastroenterol · Jun 2012
Calretinin immunohistochemistry in Hirschsprung's disease: An adjunct to formalin-based diagnosis.
This study was designed to assess the utility of calretinin immunohistochemistry in the diagnosis of Hirschsprung's disease. ⋯ Calretinin immunohistochemistry was found to be highly sensitive and specific in detecting aganglionic segments. New research should be conducted in order to clarify calretinin staining patterns of the transitional zone, rare Hirschsprung's disease types, pure hypoganglionosis patients, and the anorectal junction, and for the mapping of fetal and neonatal colonic specimens. The technique seemed very effective for lowering the need for excessive sectioning and practical regarding the erratic nature of the acetylcholinesterase staining.
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Turk J Gastroenterol · Feb 2012
Effect of beta-glucan in lung damage secondary to experimental obstructive jaundice.
This study aimed at investigating the protective effects of beta-glucans on the lungs in obstructive jaundice. ⋯ This study suggests that beta-glucan exhibits protective effect in pulmonary tissue against oxidative damage in obstructive jaundice.
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Turk J Gastroenterol · Feb 2012
Letter Case ReportsIleocolic intussusception due to a gastrointestinal stromal tumor.