Articles: pruritus.
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Uremic pruritus (UP) significantly compromises the quality of life in patients with end-stage renal disease undergoing peritoneal dialysis. Although the precise pathophysiological mechanisms of UP remain elusive, the thalamus, which is integral to processing sensory information, is potentially implicated in its development. This study aimed to investigate alterations in the structure and resting-state functional connectivity (rsFC) of thalamic subregions in patients with UP. ⋯ The decreased volume of thalamic subregions and rsFC were closely associated with UP severity. It was found that the volume of R_Stha directly influences the severity of pruritus in UP patients, but this effect does not manifest through rsFC between R_Stha and left supplementary motor area or left paracentral lobule. Patients with UP exhibited changes in structural and functional connectivity within specific thalamic subregions, providing neuroimaging insights into the neural mechanisms of UP.
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Chronic pruritus accounts for approximately 1 % of all physician visits, and providers are often confronted with how to treat patients with pruritus. Scabies is oftentimes a concern by both patients and providers, and anti-scabietic treatments are generally considered safe and effective. However, the pruritus will continue if there is an alternate etiology. ⋯ While scabies is one cause of chronic pruritus, its misdiagnosis may increase the chance that at-risk individuals, often those with prior substance abuse or psychiatric disorders, develop a persistent concern for ongoing infestation. It is possible that, in treating chronic pruritus with repeated empiric anti-scabietic treatments, the prescribing physician may contribute to the development of DI. We review the approach to a patient with chronic pruritus and ways to avoid unnecessary repeated anti-scabietic treatments.
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Pruritus, a common symptom of burn wounds, arises from skin tissue damage and abnormal tissue healing. Chronic post-burn pruritus (CPBP) is defined as itching that persists for six weeks or more. The brain mechanisms underlying CPBP are not understood adequately. This study aims to explore abnormal brain function in CPBP patients and identify potential pathogenesis of pruritus. ⋯ Our data suggest that patients with CPBP show alterations in ReHo, ALFF, and fALFF values primarily in brain regions associated with the default mode network and sensorimotor areas. These results may provide valuable insights relevant to the neuropathology of CPBP.
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Aims/Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder globally. Crisaborole, a nonsteroidal topical phosphodiesterase 4 inhibitor (PDE4i), has been utilized in treating AD. Crisaborole regulates the production of inflammatory cytokines, which are usually overactive among AD patients. ⋯ Furthermore, the safety profiling of the treatments was insignificant, demonstrating no statistical difference in the treatment-emergent adverse events (TEAEs) between the two groups with high heterogeneity (OR 0.53, 95% CI 0.14 to 1.98; I2 = 99%; p = 0.35). Conclusion Crisaborole demonstrates substantial efficacy in treating mild to moderate AD compared to vehicle therapies, as it reduces the signs and symptoms of the disease. Furthermore, crisaborole is well tolerated and has an acceptable safety profile in treating mild to moderate AD patients.
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J Pain Symptom Manage · Jan 2025
Review Meta AnalysisEfficacy and Safety of Pregabalin and Gabapentin for Pruritus: A systematic review and meta-analysis.
Limited data existed on the efficacy and safety of novel antiepileptic drugs (pregabalin and gabapentin) in treating pruritus. ⋯ The novel antiepileptic drugs pregabalin and gabapentin demonstrated significant therapeutic value in the treatment of pruritus, with a favorable safety profile. Compared to commonly used pruritus treatments such as antihistamines and antidepressants, these medications offered a promising alternative.