Article Notes
Article pearls, summaries and comments.
Ioannidis demonstrated that 80% of non-randomized studies were wrong, and among randomized controlled studies 25% were incorrect. Even large, multicenter, randomized clinical trials were predictably wrong in 10% of studies.
Ioannidis JP. Why most published research findings are false. PLoS Med. 2005 Aug 1; 2 (8): e124e124.
Note that this was firstly a retrospective trial, and secondly that it was a re-analysis of data from an earlier study, the 'Vitamins In Nitrous Oxide trial', and as such not designed with assessment of this article's end point in mind.
Nonetheless an interesting and relevant finding that calls in to question the idea that intra-operative N2O has post-operative analgesia benefit via it's known NMDA antagonism. As with many things, *further studies are required"...