Post-op nausea & vomiting incidence is related to duration of nitrous oxide exposure, but is clinically insignificant at under 1 hour exposure.
Drug treatment for pulmonary hypertension improved 6-minute walk distance and reduced hospitalisation. Combination is more effective than monotherapy.
12-16h of post-op supplemental O2 (80%) does not reduce wound infection or complication in the morbidly obese undergoing gastric bypass.
Addition of paracetamol or NSAIDs significantly reduces post-operative opioid consumption in children, although not demonstrably opioid side effects.
Perineural dexamethasone may improve post-op analgesia for sciatic blocks but not for ankle blocks when compared with systemic dexamethasone.
Intraoperative nitrous oxide use does not improve post-operative analgesia or reduce opioid consumption.
Note that this was firstly a retrospective trial, and secondly that it was a re-analysis of data from an earlier study, the 'Vitamins In Nitrous Oxide trial', and as such not designed with assessment of this article's end point in mind.
Nonetheless an interesting and relevant finding that calls in to question the idea that intra-operative N2O has post-operative analgesia benefit via it's known NMDA antagonism. As with many things, *further studies are required"...
Greater depth of general anaesthesia as measured by Bispectral Index Score (target BIS 30-40) does not reduce post-operative pain.
Adjuvant perineural dexamethasone (4-10 mg) prolongs brachial plexus sensory and motor blockade by between 65% and 100% longer.
Peri-operative nicotine very slightly reduces opioid consumption in non-smokers but not pain scores — and increases the incidence of post-op nausea.