International journal of clinical practice
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisEffect of Artemisia extract on glycemic control: A systematic review and meta-analysis of randomized controlled trial.
Animal and human studies have indicated anti-diabetic effect of Asteraceae. The present study aimed to systematically review and analyse randomized controlled trials assessing the effect of Artemisia extract on glycemic status in patients with impaired glycemic control. ⋯ Supplementation with Artemisia extract may reduce HOMA-IR, but beneficial effects on other markers such as FBG requires further investigations.
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Int. J. Clin. Pract. · Nov 2021
Letter Review Meta AnalysisPrevalence of comorbid tuberculosis amongst COVID-19 patients: A rapid review and meta-analysis.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisEffects of dehydroepiandrosterone (DHEA) supplementation on cortisol, leptin, adiponectin, and liver enzyme levels: a systematic review and meta-analysis of randomized clinical trials.
Dehydroepiandrosterone (DHEA) supplementation has been investigated in patients with altered cortisol levels and is proposed to ameliorate the metabolic profile related to adipose tissue. However, further research is warranted and evidence is no compelling for liver safety. Hence, we aimed to meta-analyse the effects of DHEA supplementation on circulating levels of cortisol, liver enzymes, and adipokines. ⋯ DHEA supplementation decreased circulating cortisol but did not alter adiponectin, leptin, AST, and ALT levels. Hence, DHEA supplementation could be considered as an adjunct in the management of hypercortisolaemia and is safe for the liver.
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialEvaluation of Ultrasound-Guided Adductor Canal Block With Two Different Concentration of Bupivacaine in Arthroscopic Knee Surgery, A Feasibility Study.
The application of regional anaesthesia techniques as a component of multimodal analgesia in knee arthroscopic surgeries increases the quality of postoperative analgesia. Adductor canal block (ACB) is an effective "motor sparing" analgesia technique used in knee surgeries. This study aimed to evaluate the efficacy of ACB using two different concentrations of local anaesthetic in terms of analgesic requirements and pain density in patients undergoing knee arthroscopy. ⋯ In arthroscopic knee surgery, ACB interventions with 0.25% and 0.16% concentrations of bupivacaine were similar in terms of postoperative analgesic efficacy, and they increased the quality of multimodal analgesics when compared with the control group.
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Int. J. Clin. Pract. · Nov 2021
Randomized Controlled TrialThe Participation of Arab Women in Randomized Clinical Trials for Cardiovascular Diseases.
Women's enrolment in randomised clinical trials (RCTs) raises the attention of medical personnel and evidence-based medicine researchers to achieve the highest possible quality and transparency of conducted studies. This study aims to demonstrate various patterns and relationships of women's enrolment in cardiovascular RCTs conducted in Arab countries. ⋯ As a result of the huge importance of RCTs in the medical field, and to reduce biases arising from inaccurate representation of different study populations, women's enrolment in Arab cardiovascular trials should be pre-planned and based on the percentage of women among the studied disease population.