Knowledge

Collections of articles, notes and knowledge from the metajournal community.

Ventilation in the ED

Emergency medicine Ventilation
- Multicenter Study
  
  Initial mechanical ventilator settings and lung protective ventilation in the ED.
  
  Am J Emerg Med. 2016 Aug 1; 34 (8): 1446-51.
- Review
  
  Managing Initial Mechanical Ventilation in the Emergency Department.
  
  Ann Emerg Med. 2016 Nov 1; 68 (5): 614-617.
- Article
  
  The use of mechanical ventilation in the ED.
  
  Am J Emerg Med. 2012 Sep 1;30(7):1183-8.
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Advanced age and anesthesia

Anesthesia Frailty Perioperative medicine
- Observational Study
  
  Mortality, Geriatric, and Nongeriatric Surgical Risk Factors Among the Eldest Old: A Prospective Observational Study.
  
  Anesth. Analg. 2017 Oct 1; 125 (4): 1329-1336.
- Observational Study
  
  The Association of Frailty With Outcomes and Resource Use After Emergency General Surgery: A Population-Based Cohort Study.
  
  Anesth. Analg. 2017 May 1; 124 (5): 1653-1661.
- Observational Study
  
  Comprehensive geriatric assessment predicts mortality and adverse outcomes in hospitalized older adults.
  
  BMC Geriatr. 2014 Jan 1;14:129.
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Paravertebral block for post-operative nephrectomy analgesia

Regional anesthesia
Continuous paravertebral block is an effective alternative to thoracic epidural for managing post-operative pain after open nephrectomy, with a better side-effect profile.
pearl

...and 1 more note
- Article
  
  Paravertebral block provides significant opioid sparing after hand-assisted laparoscopic nephrectomy: an expanded case report of 30 patients.
  
  J. Endourol. 2009 Dec 1;23(12):1979-83.
- Randomized Controlled Trial
  
  Thoracic paravertebral block for nephrectomy: a randomized, controlled, observer-blinded study.
  
  Pain Med. 2014 May 1;15(5):850-6.
- Article
  
  Comparative Evaluation of Continuous Thoracic Paravertebral Block and Thoracic Epidural Analgesia Techniques for Post-operative Pain Relief in Patients Undergoing Open Nephrectomy: A Prospective, Randomized, Single-blind...
  
  Anesth Essays Res. 2017 Apr 1; 11 (2): 359-364.
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What are Calabadions? Can they replace sugammadex?

Neuromuscular agents Sugammadex
Calabadions are heterocyclics molecule that offers rapid and complete reversal of both aminosteroids, such as rocuronium and vecuronium, and benzylisoquinoline NMBDS, such as atracurium and cisatracurium.

Notably, calabadion 2 binds rocuronium 89 times stronger than sugammadex. Additionally it also binds etomidate and ketamine.

Calabadions are still undergoing pre-human animal testing, and so are some time away from entering clinical practice.
summary
- Article
  
  Calabadion: A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents.
  
  Anesthesiology. 2013 Aug 1;119(2):317-25.
- Comparative Study
  
  Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents.
  
  Anesthesiology. 2015 Dec 1;123(6):1337-49.
- Article
  
  A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.
  
  Anesthesiology. 2016 Aug 1; 125 (2): 333-45.
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Perioperative stroke

Cerebrovascular Perioperative medicine Postoperative complications
- Review
  
  Perioperative stroke.
  
  Can J Anaesth. 2016 Feb 1; 63 (2): 193-204.
- Article
  
  Time elapsed after ischemic stroke and risk of adverse cardiovascular events and mortality following elective noncardiac surgery.
  
  JAMA. 2014 Jul 16;312(3):269-77.
  
  Elective surgery should be delayed at least 9 months after stroke or cerebrovascular event, although there is a persisting increased risk of perioperative stroke in these patients.
  pearl
- Multicenter Study
  
  Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study.
  
  Lancet. 2019 Sep 21; 394 (10203): 1022-1029.
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