Knowledge

Collections of articles, notes and knowledge from the metajournal community.

Perioperative & Regional Dexmedetomidine

Dexmedetomidine
- Review
  
  Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: a systematic review and meta-analysis.
  
  Br J Anaesth. 2013 Jun 1; 110 (6): 915-25.
- Randomized Controlled Trial
  
  Dexmedetomidine Added to Ropivacaine Extends the Duration of Interscalene Brachial Plexus Blocks for Elective Shoulder Surgery When Compared with Ropivacaine Alone: A Single-Center, Prospective, Triple-Blind, Randomized...
  
  Reg Anesth Pain Med. 2014 Jan 1; 39 (1): 37-47.
  
  Dexmedetomidine 150 mcg significantly extends the duration of ropivacaine interscalene block by almost 30% without significant adverse effect.
  pearl
- Review
  
  Dexmedetomidine: review, update, and future considerations of paediatric perioperative and periprocedural applications and limitations.
  
  Br J Anaesth. 2015 Aug 1; 115 (2): 171-82.
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Common anesthesia drug interactions

Complications Drugs
- Review
  
  The effect of ondansetron on the efficacy of postoperative tramadol: a systematic review and meta-analysis of a drug interaction.
  
  Anaesthesia. 2015 Feb 1; 70 (2): 209-18.
  
  It is likely that there is an interaction between tramadol and ondansetron that decreases the early-postoperative analgesic efficacy of tramadol.
  pearl
- Randomized Controlled Trial
  
  Analgesic interaction between ondansetron and acetaminophen after tonsillectomy in children: The Paratron randomized, controlled trial.
  
  Eur J Pain. 2015 May 1;19(5):661-8.
  
  Ondansetron may reduce the analgesic effect of acetaminophen/paracetamol.
  pearl
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Peri-operative beta blockade

Cardiovascular Perioperative medicine
- Randomized Controlled Trial
  
  Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.
  
  Lancet. 2008 May 31;371(9627):1839-47.
  
  Perioperative metoprolol in at-risk patients undergoing non-cardiac surgery reduced major cardiovascular adverse events but increased mortality.
  pearl
- Randomized Controlled Trial
  
  Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery.
  
  Eur. Heart J.. 2001 Aug 1;22(15):1353-8.
- Randomized Controlled Trial
  
  Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomized controlled trial (DECREASE-IV).
  
  Ann. Surg.. 2009 Jun 1;249(6):921-6.
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The History of Anesthesia

Anesthesia History
Papers focusing on the history of anesthesia – both modern articles and the original historical, landmark articles themselves.
summary
- Biography
  
  Mastectomy without anesthesia: the cases of Abigail Adams Smith and Fanny Burney.
  
  Am. J. Med.. 2011 May 1;124(5):474.
- Biography
  
  Horace Wells (1815-1848).
  
  Anaesth Intensive Care. 1996 Aug 1;24(4):415.
- Biography
  
  Lessons from history: Horace Wells and the moral features of clinical contexts.
  
  Anesth Prog. 1995 Jan 1;42(1):1-6.
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Does perioperative pregabalin reduce postoperative pain?

Pain Pregabalin
- Review
  
  Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis.
  
  Br J Anaesth. 2015 Jan 1; 114 (1): 10-31.
  
  Perioperative pregabalin may improve postoperative analgesia, nausea and vomiting, though increases sedation and visual disturbances
  pearl
- Randomized Controlled Trial
  
  A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy.
  
  Can J Anaesth. 2014 Jun 1;61(6):551-7.
- Review
  
  Efficacy of pregabalin in acute postoperative pain: a meta-analysis.
  
  Br J Anaesth. 2011 Apr 1;106(4):454-62.
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