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  Anesthesia & Perioperative Contribution to the Opioid Epidemic

  • Article

    Association of Opioid Prescribing With Opioid Consumption After Surgery in Michigan.

    JAMA Surg. 2019 Jan 1; 154 (1): e184234.

    The single greatest predictor of the amount of opioid used after surgical discharge is the amount of postoperative opioid prescribed.

    pearl

  • Article

    Association of Lowering Default Pill Counts in Electronic Medical Record Systems With Postoperative Opioid Prescribing.

    JAMA Surg. 2018 Nov 1; 153 (11): 1012-1019.

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  What contribution does anesthesia make to climate change?

  Also see Carbon Footprint from Anaesthetic gas use [pdf] from the UK’s Sustainable Development Unit.

  

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  • Article

    Inhalation anaesthetics and climate change.

    Br J Anaesth. 2010 Dec 1;105(6):760-6.

  • Editorial

    Climate effect of inhaled anaesthetics.

    Br J Anaesth. 2010 Dec 1; 105 (6): 731-3.

  • Article

    Global warming potential of inhaled anesthetics: application to clinical use.

    Anesth. Analg. 2010 Jul 1;111(1):92-8.

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  Retracted anesthesia & perioperative medicine publications

  Metajournal now automatically tracks and can filter for retracted articles – simply hit search in your article view and filter by article type. Easily check if there are any retracted articles among those you’ve favourited or read previously.

  It’s a sad indictment on a minority in the medical community that this kind of technology is now necessary...

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  • Review

    Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.

    J Bone Joint Surg Am. 2007 Jun 1;89(6):1343-58.

  • Randomized Controlled Trial

    Evaluation of the safety and efficacy of the perioperative administration of rofecoxib for total knee arthroplasty.

    J Arthroplasty. 2002 Jan 1;17(1):26-31.

  • Randomized Controlled Trial

    Ramosetron compared with granisetron for the prevention of vomiting following strabismus surgery in children.

    Br J Ophthalmol. 2001 Jun 1;85(6):670-2.

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  What are Calabadions? Can they replace sugammadex?

  Calabadions are heterocyclics molecule that offers rapid and complete reversal of both aminosteroids, such as rocuronium and vecuronium, and benzylisoquinoline NMBDS, such as atracurium and cisatracurium.

  Notably, calabadion 2 binds rocuronium 89 times stronger than sugammadex. Additionally it also binds etomidate and ketamine.

  Calabadions are still undergoing pre-human animal testing, and so are some time away from entering clinical practice.

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  • Article

    Calabadion: A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents.

    Anesthesiology. 2013 Aug 1;119(2):317-25.

  • Comparative Study

    Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents.

    Anesthesiology. 2015 Dec 1;123(6):1337-49.

  • Article

    A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.

    Anesthesiology. 2016 Aug 1; 125 (2): 333-45.

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  Paravertebral block for post-operative nephrectomy analgesia

  Continuous paravertebral block is an effective alternative to thoracic epidural for managing post-operative pain after open nephrectomy, with a better side-effect profile.

  pearl

  
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  • Article

    Paravertebral block provides significant opioid sparing after hand-assisted laparoscopic nephrectomy: an expanded case report of 30 patients.

    J. Endourol. 2009 Dec 1;23(12):1979-83.

  • Randomized Controlled Trial

    Thoracic paravertebral block for nephrectomy: a randomized, controlled, observer-blinded study.

    Pain Med. 2014 May 1;15(5):850-6.

  • Article

    Comparative Evaluation of Continuous Thoracic Paravertebral Block and Thoracic Epidural Analgesia Techniques for Post-operative Pain Relief in Patients Undergoing Open Nephrectomy: A Prospective, Randomized, Single-blind...

    Anesth Essays Res. 2017 Apr 1; 11 (2): 359-364.

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